AMT : aminomethyltransferase
Description
The AMT gene encodes for the enzyme amidophosphoribosyl transferase, which plays a crucial role in the synthesis of purine nucleotides, essential building blocks for DNA and RNA. AMT catalyzes the first committed step in purine biosynthesis, converting phosphoribosyl pyrophosphate (PRPP) to 5-phospho-α-D-ribosylamine, a key precursor for adenine and guanine. This process is critical for cell growth, repair, and overall metabolic function. Dysregulation of AMT activity can lead to various metabolic disorders, highlighting the importance of this gene in human health.
Associated Diseases
Did you know?
AMT is highly conserved across different species, indicating its essential role in fundamental cellular processes.
