ALG1 : ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase
Description
The ALG1 (ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase) is a protein-coding gene located on chromosome 16.
The ALG1 gene provides instructions for making an enzyme involved in glycosylation, a process where complex sugar chains (oligosaccharides) attach to proteins and fats (lipids). Glycosylation modifies proteins for proper function and lipids for cell interactions. Oligosaccharides are built step-wise, and the ALG1 enzyme adds a simple sugar, mannose, to the growing chain at a specific step. Once the correct number of sugar molecules are linked, the oligosaccharide attaches to a protein or lipid.
ALG1 catalyzes the addition of the first mannose residue to a dolichol-lipid linked oligosaccharide intermediate, which is essential for proper N-linked glycosylation.
ALG1 is also known as CDG1K, HMAT1, HMT-1, HMT1, MT-1, Mat-1, hMat-1.
