ALDH6A1

Description

ALDH6A1, also known as aldehyde dehydrogenase 6A1, encodes a crucial enzyme involved in the detoxification of aldehydes, particularly those generated by alcohol metabolism. This gene plays a vital role in various cellular processes, including oxidative stress protection, inflammation regulation, and steroid hormone synthesis. ALDH6A1 mutations can lead to several inherited diseases, impacting various organs and systems. Ongoing research aims to further understand the complexities of ALDH6A1‘s functions and develop strategies for preventing and treating associated diseases.

Associated Diseases

• Sjogren-Larsson syndrome (SLS)
• Spinal muscular atrophy with respiratory distress type 1 (SMARD1)
• Neurodevelopmental disorders
• Mitochondrial dysfunction

Did you know?

ALDH6A1 has a unique ability to process both short- and long-chain aldehydes, making it a versatile player in detoxification pathways.