AICDA
Description
The AICDA gene, also known as activation-induced cytidine deaminase, plays a crucial role in the adaptive immune system. It encodes an enzyme that is essential for the process of somatic hypermutation and class-switch recombination in B lymphocytes. These processes are responsible for generating antibody diversity and fine-tuning the immune response to specific antigens. AICDA‘s activity leads to targeted mutations in antibody genes, resulting in antibodies with improved affinity and specificity for their target antigens. This intricate mechanism allows the immune system to adapt and mount effective responses to a wide range of pathogens.
Associated Diseases
Did you know?
AICDA‘s activity is tightly regulated to prevent unwanted mutations in other parts of the genome, which could lead to cancer or other diseases.
