AGTR1 : angiotensin II receptor type 1
Description
The AGTR1 gene, located on chromosome 3, encodes the angiotensin II type 1 receptor (AT1R), a protein that plays a crucial role in regulating blood pressure and cardiovascular function. AT1R is a G protein-coupled receptor that binds to angiotensin II, a potent vasoconstrictor hormone. Upon binding, AT1R activates downstream signaling pathways, leading to a cascade of cellular responses, including vasoconstriction, aldosterone release, and sodium retention. These effects contribute to the maintenance of blood pressure and fluid balance.
Associated Diseases
Did you know?
Mutations in the AGTR1 gene can cause rare genetic disorders affecting blood pressure and electrolyte balance.
