AGT : angiotensinogen
Description
The AGT (angiotensinogen) is a protein-coding gene located on chromosome 1.
The AGT gene provides instructions for making a protein called angiotensinogen. This protein is part of the renin-angiotensin system, which regulates blood pressure and the balance of fluids and salts in the body. The first step in this process involves converting angiotensinogen to angiotensin I. Then, angiotensin I is converted to angiotensin II. Angiotensin II causes blood vessels to narrow (constrict), leading to increased blood pressure. It also stimulates the production of the hormone aldosterone, which causes the kidneys to absorb salt and water. The increased fluid in the body further raises blood pressure. Proper blood pressure during fetal development is crucial for normal kidney development, particularly the proximal tubules, and other tissues. Additionally, angiotensin II may directly influence kidney development by affecting growth factors involved in the development of kidney structures.
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
AGT is also known as ANHU, SERPINA8, hFLT1.
