AGT : angiotensinogen

The AGT Gene: A Key Player in Blood Pressure Regulation and Fetal Development


The AGT (angiotensinogen) gene provides the instructions for producing the protein angiotensinogen, a vital component of the renin-angiotensin system (RAS). The RAS is a complex hormonal network that plays a crucial role in regulating blood pressure, maintaining fluid and electrolyte balance, and influencing kidney development.

Associated Diseases

Mutations in the AGT gene have been linked to various diseases, including:

  • Hypertension: High blood pressure is a condition where the force exerted by blood against the blood vessel walls is abnormally elevated. Mutations in AGT can lead to increased angiotensinogen levels, exacerbating hypertension.
  • Nephrogenic Diabetes Insipidus: A condition characterized by excessive water loss and inadequate urine concentration, often resulting from impaired kidney function. Mutations in AGT can impair angiotensin II production, affecting water reabsorption in the kidneys.
  • Fetal Growth Restriction: Compromised fetal growth during pregnancy can result from impaired angiotensin II signaling, leading to insufficient blood supply to the developing tissues.

Did you Know ?

Approximately 15% of individuals with essential hypertension (high blood pressure without an identifiable cause) have genetic variations in the AGT gene. These variations contribute to the elevation of blood pressure.

Disclaimer: The information provided here is not exhaustive by any means. Always consult your doctor or other qualified healthcare provider with any questions you may have regarding a medical condition, procedure, or treatment, whether it is a prescription medication, over-the-counter drug, vitamin, supplement, or herbal alternative.