AGPAT2 : 1-acylglycerol-3-phosphate O-acyltransferase 2

The AGPAT2 Gene: A Key Player in Fat Metabolism and Health


The AGPAT2 gene provides the blueprint for an enzyme called 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2). This enzyme is found in various cells and tissues and plays a pivotal role in the synthesis of two major types of fats: glycerophospholipids and triacylglycerols.

Glycerophospholipids are the building blocks of cell membranes and facilitate intracellular communication. Triacylglycerols, also known as triglycerides, are stored in fat cells and serve as an energy reserve for the body.

Associated Diseases

Mutations in the AGPAT2 gene can disrupt fat metabolism and lead to several health conditions, including:

  • Dunnigan-type familial partial lipodystrophy (FPLD2): A rare genetic disorder characterized by an almost complete absence of adipose tissue (fat) in the limbs and buttocks.
  • Hypertriglyceridemia: Elevated levels of triglycerides in the blood, increasing the risk of heart disease and stroke.
  • Obesity and type 2 diabetes: AGPAT2 has been linked to the development of these metabolic disorders.

Did you Know ?

Defects in the AGPAT2 gene account for approximately 10% of FPLD2 cases.

Disclaimer: The information provided here is not exhaustive by any means. Always consult your doctor or other qualified healthcare provider with any questions you may have regarding a medical condition, procedure, or treatment, whether it is a prescription medication, over-the-counter drug, vitamin, supplement, or herbal alternative.