AGK
Description
The AGK gene, also known as Aurora kinase A, plays a crucial role in cell division and growth. It encodes a protein kinase that regulates various processes during mitosis, including chromosome segregation, spindle formation, and centrosome maturation. The AGK gene is highly conserved across species, indicating its fundamental importance in cellular function. Aberrant AGK expression or mutations can lead to uncontrolled cell proliferation and contribute to the development of various cancers.
Associated Diseases
- Cancer (e.g., breast cancer, colorectal cancer, lung cancer)
- Neurological disorders (e.g., neuroblastoma, glioblastoma)
- Developmental defects (e.g., microcephaly, skeletal abnormalities)
Did you know?
AGK is a highly selective target for anti-cancer drug development due to its crucial role in cell division and its overexpression in many cancers.
