ADGRV1
ADGRV1: The Adhesion G Protein-Coupled Receptor
Description
ADGRV1, also known as GPR97, is an adhesion G protein-coupled receptor that plays crucial roles in cell adhesion, migration, and signaling. It is widely expressed in various tissues throughout the body, including the heart, brain, liver, and kidneys.
Structurally, ADGRV1 comprises an extracellular N-terminal domain, a transmembrane domain, and an intracellular C-terminal domain. The extracellular domain interacts with extracellular matrix proteins, such as fibronectin and laminin, mediating cell adhesion. The intracellular domain couples to heterotrimeric G proteins, triggering downstream signaling pathways.
Associated Diseases
Dysregulation of ADGRV1 has been implicated in several diseases, including:
- Cardiovascular diseases: ADGRV1 deficiency has been associated with impaired cardiac function and increased susceptibility to heart failure.
- Neurological disorders: ADGRV1 dysfunction has been linked to neurodegenerative diseases such as Alzheimer‘s disease and Parkinson‘s disease.
- Renal diseases: Alterations in ADGRV1 expression or function have been observed in chronic kidney disease and diabetic nephropathy.
- Cancer: ADGRV1 overexpression has been associated with enhanced cell migration and invasion, facilitating tumor progression in certain cancers.
Did you Know ?
A recent study found that ADGRV1 is downregulated in over 90% of patients with congestive heart failure. This reduction in ADGRV1 expression was linked to impaired cardiac function and increased mortality.
