ADAMTS17
ADAMTS17: A Versatile Enzyme with Intriguing Roles in Health and Disease
Description
ADAMTS17 (a disintegrin and metalloproteinase with thrombospondin motifs 17) is a member of the ADAMTS family of proteins. These enzymes play crucial roles in various biological processes, including extracellular matrix remodeling, proteolysis, and angiogenesis. ADAMTS17, in particular, is known for its involvement in cartilage homeostasis, vascular biology, and immune responses.
Associated Diseases
ADAMTS17 has been implicated in several human diseases, including:
- Osteoarthritis (OA): Decreased ADAMTS17 activity has been associated with increased cartilage degradation and OA progression.
- Cardiovascular disease (CVD): ADAMTS17 plays a role in vascular remodeling and plaque stability. Its dysregulation can contribute to plaque formation and CVD.
- Autoimmune diseases: ADAMTS17 is involved in regulating immune responses and has been associated with autoimmune conditions such as rheumatoid arthritis.
- Cancer: ADAMTS17 has been implicated in tumor angiogenesis and metastasis. Its expression levels may be altered in various types of cancer.
Did you Know ?
- Over 30% of people with OA have reduced ADAMTS17 activity, highlighting the potential significance of this enzyme in cartilage health.
