ABCG5 : ATP binding cassette subfamily G member 5

The Intriguing Role of ABCG5 and ABCG8 Genes in Regulating Cholesterol and Plant Sterol Absorption

Description

Embedded within our genetic blueprint lie the ABCG5 and ABCG8 genes, responsible for synthesizing two crucial proteins known as sterolin-1 and sterolin-2. Together, these proteins form the sterolin complex, which plays a pivotal role in regulating the absorption and elimination of plant sterols and cholesterol from our diet.

Associated Diseases

Defects in ABCG5 and ABCG8 genes can lead to a rare condition called sitosterolemia, characterized by the accumulation of plant sterols in the body. This can result in a range of health issues, including accelerated atherosclerosis (narrowing of arteries), liver disease, and nervous system disorders.

Did you Know ?

Plant sterols account for approximately 15% of the sterols in our diet. However, only about 5% of these sterols are absorbed into the bloodstream, thanks to the efficient elimination mechanism facilitated by sterolin.