PRDX3
Description
The PRDX3 (peroxiredoxin 3) is a protein-coding gene located on chromosome 10.
PRDX3 is a mitochondrial antioxidant enzyme belonging to the peroxiredoxin family. It exhibits significant sequence similarity to the C22 subunit of Salmonella typhimurium alkylhydroperoxide reductase and is highly conserved between humans and mice. PRDX3 plays a crucial role in protecting cells against oxidative stress and has been implicated in regulating cell proliferation and differentiation. Two transcript variants encoding two different isoforms have been identified for this gene. PRDX3 interacts with MAP3K13 and has been shown to be a valuable biomarker for the diagnosis and assessment of hepatocellular carcinoma. It also protects MCF-7 breast cancer cells against doxorubicin-mediated toxicity.
PRDX3 is a thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. It plays a crucial role in protecting cells from oxidative stress by detoxifying peroxides. PRDX3 also acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol. Furthermore, it is thought to be important for maintaining physical strength, although this is based on similarity to other proteins.
PRDX3 is also known as AOP-1, AOP1, HBC189, MER5, PPPCD, PRO1748, SCAR32, SP-22, prx-III.
Associated Diseases
- Spinocerebellar ataxia, autosomal recessive 32
- Corneal dystrophy, punctiform and polychromatic pre-Descemet
