PRDX2
Description
The PRDX2 (peroxiredoxin 2) is a protein-coding gene located on chromosome 19.
Peroxiredoxin-2 is a protein encoded by the PRDX2 gene in humans. It belongs to the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. PRDX2 may contribute to antioxidant protection in cells and antiviral activity in CD8(+) T-cells. This protein might have a proliferative effect and play a role in cancer development or progression. The crystal structure of PRDX2 has been resolved to 0.27 nm (2.7 angstroms). Multiple transcript variants encoding distinct isoforms have been identified for this gene.
PRDX2 is a thiol-specific peroxidase that converts hydrogen peroxide and organic hydroperoxides into water and alcohols, respectively. This enzyme plays a crucial role in protecting cells against oxidative stress by detoxifying peroxides. It also acts as a sensor for hydrogen peroxide-mediated signaling events, potentially influencing the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentration of H₂O₂.
PRDX2 is also known as HEL-S-2a, NKEF-B, NKEFB, PRP, PRX2, PRXII, PTX1, TDPX1, TPX1, TSA.
Associated Diseases
- Alzheimer disease
- Parkinson disease
- multiple sclerosis
- lysosomal storage disease
- endometrial cancer
- urinary bladder cancer
