PRDM7
Description
The PRDM7 (PR/SET domain 7) is a protein-coding gene located on chromosome 16.
PRDM7 is a histone methyltransferase that specifically adds a methyl group to the fourth lysine residue (Lys-4) of dimethylated histone H3 (H3K4me2), converting it to trimethylated Lys-4 histone H3 (H3K4me3). This modification is thought to be important for establishing an active chromatin state, which allows genes to be transcribed.
PRDM7 is also known as PFM4, ZNF910.
Associated Diseases
- partial chromosome Y deletion
- spermatogenic failures 50
- spermatogenic failure 25
- spermatogenic failure, X-linked, 2
- male infertility with teratozoospermia due to single gene mutation
- spermatogenic failure 61
- spermatogenic failure 73
- spermatogenic failure 74
- spermatogenic failure 48
- isochromosomy Yp
- spermatogenic failure 63
- spermatogenic failure 23
