PRDM6
Description
The PRDM6 (PR/SET domain 6) is a protein-coding gene located on chromosome 5.
PRDM6, also known as PR domain zinc finger protein 6, is a protein that acts as a transcriptional repressor of smooth muscle gene expression. It plays a role in the transition from differentiated to proliferative smooth muscle by suppressing differentiation and maintaining the proliferative potential of vascular smooth muscle cells. PRDM6 also affects endothelial cells by inhibiting their proliferation, survival, and differentiation. The exact mechanism of PRDM6's action remains unclear, with some research suggesting it acts as a histone methyltransferase, while others propose it functions through the recruitment of other proteins like EHMT2/G9a. Regardless of the exact mechanism, PRDM6's role in gene repression is established, potentially involving the methylation of histone H4 at lysine 20, a marker of epigenetic transcriptional repression.
PRDM6 is also known as KMT8C, PDA3, PRISM.
