PPP3R2
Description
The PPP3R2 (protein phosphatase 3 regulatory subunit B, beta) is a protein-coding gene located on chromosome 9.
Calcineurin subunit B type 2 is a protein that in humans is encoded by the PPP3R2 gene. Among its related pathways are MAPK signaling pathway and GPCR pathway. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is CHP1.
PPP3R2 is a regulatory subunit of calcineurin, a calcium-dependent, calmodulin-stimulated protein phosphatase. It confers calcium sensitivity to calcineurin.
PPP3R2 is also known as PPP3RL.
Associated Diseases
- male infertility with teratozoospermia due to single gene mutation
- spermatogenic failure 45
- spermatogenic failure 43
- spermatogenic failure 49
- spermatogenic failure 19
- spermatogenic failure 27
- spermatogenic failure 46
- spermatogenic failure 18
- spermatogenic failure 72
- spermatogenic failure 42
- spermatogenic failure 47
- spermatogenic failure 10
- spermatogenic failure 11
- spermatogenic failure 40
- spermatogenic failure, X-linked, 3
- spermatogenic failure 65
- partial chromosome Y deletion
- spermatogenic failure 39
- spermatogenic failure 41
- spermatogenic failure 3
