PPP2R3A
Description
The PPP2R3A (protein phosphatase 2 regulatory subunit B''alpha) is a protein-coding gene located on chromosome 3.
PPP2R3A is a gene that codes for a protein known as Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha. This protein is part of a larger enzyme called Protein Phosphatase 2A (PP2A), which is crucial for controlling cell growth and division. PP2A is made up of three subunits: a structural subunit A, a catalytic subunit C, and a regulatory subunit B. PPP2R3A belongs to the B'' family of regulatory subunits, which contribute to the unique properties of PP2A. Different regulatory subunits determine which molecules PP2A interacts with, where it functions within the cell, and how efficiently it removes phosphate groups from target proteins. PPP2R3A has been found to interact with other proteins involved in cell cycle control, highlighting its potential role in regulating cell growth and division. Multiple variations of PPP2R3A exist due to alternative splicing, which generates different versions of the protein with potentially different functions.
The regulatory subunit B (B'') of Protein Phosphatase 2A (PP2A) plays a crucial role in determining the enzyme's substrate specificity, its catalytic activity, and its precise location within the cell. By interacting with the core PP2A enzyme, it influences which molecules are dephosphorylated and where this dephosphorylation occurs within the cell.
PPP2R3A is also known as PPP2R3, PR130, PR72.
