PPP2R2D
Description
The PPP2R2D (protein phosphatase 2 regulatory subunit Bdelta) is a protein-coding gene located on chromosome 10.
PPP2R2D, also known as PP2A subunit B isoform delta or serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform, is a protein encoded by the PPP2R2D gene in humans. It functions as a regulatory subunit of the heterotrimeric protein phosphatase 2 enzyme.
The PPP2R2D gene encodes a regulatory subunit of protein phosphatase 2A (PP2A), a key enzyme in cell cycle control. PPP2R2D, also known as PR55-delta, is a B regulatory subunit that modulates PP2A's activity and substrate selectivity. The activity of PP2A complexes containing PPP2R2D fluctuates during the cell cycle, with high activity in interphase and low activity during mitosis. This regulation is achieved by interactions with phosphorylated ENSA and ARPP19 inhibitors during mitosis, which inhibit PP2A's activity. PPP2R2D also influences the localization of the catalytic enzyme within the cell.
PPP2R2D is also known as B55D, B55delta, MDS026.
