PPP2R2A
Description
The PPP2R2A (protein phosphatase 2 regulatory subunit Balpha) is a protein-coding gene located on chromosome 8.
PPP2R2A, the gene encoding the alpha isoform of the regulatory subunit B55 of protein phosphatase 2A (PP2A), plays a role in cell growth and division. PP2A is a major Ser/Thr phosphatase with a heterotrimeric core enzyme composed of a catalytic subunit and a constant regulatory subunit. The B regulatory subunit, encoded by PPP2R2A, influences substrate selectivity and catalytic activity. This gene encodes the alpha isoform of the B55 subfamily, contributing to the regulation of PP2A's function.
The B regulatory subunit of PP2A, encoded by PPP2R2A, influences substrate specificity and catalytic activity. It also directs the catalytic enzyme to specific cellular compartments. PPP2R2A is crucial for the dephosphorylation of WEE1 by PP2A, preventing its degradation by ubiquitination. This increases WEE1 protein levels and promotes the G2/M checkpoint.
PPP2R2A is also known as B55A, B55ALPHA, PR52A, PR55A, PR55alpha.
Associated Diseases
- lysosomal storage disease
- type 2 diabetes mellitus
- endometrial cancer
- ovarian cancer
- schizophrenia
- hereditary breast ovarian cancer syndrome
