PPP1R9B
Description
The PPP1R9B (protein phosphatase 1 regulatory subunit 9B) is a protein-coding gene located on chromosome 17.
Neurabin-2 is a protein that in humans is encoded by the PPP1R9B gene. Spinophilin is a regulatory subunit of protein phosphatase-1 catalytic subunit (PP1; see MIM 176875) and is highly enriched in dendritic spines, specialized protrusions from dendritic shafts that receive most of the excitatory input in the central nervous system (Allen et al., 1997).[supplied by OMIM]
== Interactions == PPP1R9B has been shown to interact with PPP1CB, PPP1CA, Dopamine receptor D2, P16, PPP1CC, T-cell lymphoma invasion and metastasis-inducing protein 1 and PPP1R2.
PPP1R9B, also known as Neurabin-2, is a scaffolding protein involved in various signaling pathways. It plays a crucial role in modulating excitatory synaptic transmission and dendritic spine morphology. PPP1R9B binds to actin filaments (F-actin), displaying cross-linking activity along the F-actin sides. This binding suggests its potential role in linking the actin cytoskeleton to the plasma membrane at the synapse. PPP1R9B is believed to target protein phosphatase 1 (PP1) to dendritic spines, which are rich in F-actin, regulating PP1 specificity towards ion channels and other substrates, such as AMPA and NMDA glutamate receptors. PPP1R9B contributes to G-protein coupled receptor signaling regulation, including dopamine D2 receptors and alpha-adrenergic receptors. It may establish a signaling complex for dopaminergic neurotransmission through D2 receptors by linking receptors, downstream signaling molecules, and the actin cytoskeleton. PPP1R9B binds to ADRA1B and RGS2, mediating regulation of ADRA1B signaling. It may contribute to Rac signaling specificity by binding to both RacGEFs and Rac effector proteins. PPP1R9B might regulate p70 S6 kinase activity by forming a complex with TIAM1. It is essential for hepatocyte growth factor (HGF)-induced cell migration.
PPP1R9B is also known as PPP1R6, PPP1R9, SPINO, Spn.
