PPP1R3C
Description
The PPP1R3C (protein phosphatase 1 regulatory subunit 3C) is a protein-coding gene located on chromosome 10.
PPP1R3C, also known as PTG, is an enzyme encoded by the PPP1R3C gene in humans. Protein phosphatase-1 (PP1) regulates a variety of cellular functions through reversible protein phosphorylation. PPP1R3C is a regulatory subunit of PP1 that targets it to specific locations, modulates its substrate specificity, and responds to extracellular signals. Several targeting subunits of PP1 have been identified, including PPP1R5, the glycogen-binding subunits GM, GL, PTG, and R6, PPP1R4, and the nuclear inhibitor of PP1 (PPP1R8).
PPP1R3C, also known as PTG, serves as a glycogen-targeting subunit for protein phosphatase 1 (PP1), regulating its activity. It activates glycogen synthase, decreasing glycogen phosphorylase activity and inhibiting glycogen breakdown. Notably, overexpression of PPP1R3C significantly enhances basal and insulin-stimulated glycogen synthesis in various cell types.
PPP1R3C is also known as PPP1R5, PTG.
Associated Diseases
- disorder of glycogen metabolism
- prostate cancer
- LIPE-related familial partial lipodystrophy
- hyperinsulinism due to INSR deficiency
- hyperinsulinism due to glucokinase deficiency
- obesity due to melanocortin 4 receptor deficiency
- CIDEC-related familial partial lipodystrophy
- glycogen storage disease VI
- PLIN1-related familial partial lipodystrophy
- PPARG-related familial partial lipodystrophy
