PPP1R1B
Description
The PPP1R1B (protein phosphatase 1 regulatory inhibitor subunit 1B) is a protein-coding gene located on chromosome 17.
DARPP-32, encoded by the PPP1R1B gene, is a key protein involved in dopamine signaling in the brain. It is expressed in medium-sized spiny neurons of the caudate-putamen, an area crucial for motor control and reward processing. Dopamine and glutamate signaling regulate DARPP-32 phosphorylation. Dopamine, through D1 receptors, stimulates cAMP production, leading to DARPP-32 phosphorylation, which inhibits protein phosphatase 1. Glutamate, through NMDA receptors, elevates calcium levels, activating calcineurin and dephosphorylating DARPP-32, reducing its inhibitory effect on protein phosphatase 1. This interplay between dopamine and glutamate regulates the activity of DARPP-32, influencing synaptic plasticity and dopamine-dependent signaling in the striatum. It has been suggested that DARPP-32, along with ARPP-21, might contribute to establishing a temporal window for striatal signaling.
PPP1R1B is also known as DARPP-32, DARPP32.
