PPID
Description
The PPID (peptidylprolyl isomerase D) is a protein-coding gene located on chromosome 4.
PPID can refer to several things, including:
- Peptidylprolyl isomerase D: An enzyme encoded by the PPID gene, which plays a role in protein folding.
- Pituitary pars intermedia dysfunction: A condition affecting horses.
In computer science, PPID can refer to:
- Private Personal Identifier: Used in Security Assertion Markup Language (SAML).
- Parent process ID: The process identifier of a parent process.
PPID, also known as Peptidyl-prolyl cis-trans isomerase D (PPIase D), catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides, aiding in protein folding. It acts as a co-chaperone in HSP90 complexes, particularly in unligated steroid receptor heterocomplexes. PPID competes with other co-chaperones for association with HSP90, forming distinct complexes that potentially regulate tissue-specific receptor activity. It exhibits a preference for estrogen receptor complexes and is absent in glucocorticoid receptor complexes. PPID may be involved in the cytoplasmic dynein-dependent movement of receptors from the cytoplasm to the nucleus. It can regulate MYB by inhibiting its DNA-binding activity. PPID is involved in AHR signaling by promoting AHR:ARNT dimer formation, a process independent of HSP90 but requiring chaperone activity. It also plays a role in regulating UV radiation-induced apoptosis and promotes cell viability in ALK+ ALCL cell lines.
PPID is also known as CYP-40, CYPD.
