PPIC
Description
The PPIC (peptidylprolyl isomerase C) is a protein-coding gene located on chromosome 5.
PPIC, encoded by the PPIC gene on chromosome 5, is a peptidyl-prolyl cis-trans isomerase (PPIase) that catalyzes the cis-trans isomerization of proline imidic peptide bonds. This activity facilitates protein folding and repair. PPIC participates in various biological processes, including mitochondrial metabolism, apoptosis, redox, and inflammation. It's implicated in diseases like ischemic reperfusion injury, AIDS, and cancer. PPIC forms a β-barrel structure with a hydrophobic core, consisting of eight anti-parallel β-strands capped by two α-helices. The β-turns and loops contribute to the barrel's flexibility. PPIC has 212 residues and a hydrophobic, ER-targeting sequence at the N-terminal. The PPIase domain is homologous to PPIA and can be bound and inhibited by CsA. PPIases are highly conserved and found in various organisms, including eubacteria, eukaryotes, and some archaebacteria.
PPIC is also known as CYPC.
Associated Diseases
- diverticulitis
- neutropenia, severe congenital, 2, autosomal dominant
- combined immunodeficiency with skin granulomas
- immunodeficiency 19
- immunodeficiency 18
- common variable immunodeficiency
- immunodeficiency 105
- agammaglobulinemia 7, autosomal recessive
- reticular dysgenesis
