POU2AF1
Description
The POU2AF1 (POU class 2 homeobox associating factor 1) is a protein-coding gene located on chromosome 11.
POU2AF1 is a protein encoded by the POU2AF1 gene in humans. It is also known as OCAB, OBF1, or BOB1, and functions as a transcriptional coactivator primarily expressed by B-cell lymphocytes. BOB1 regulates the expression of immunoglobulin and other genes essential for B-cell function, including CD20, CRISP-3, and CD36. Its expression is a useful marker for identifying certain lymphomas as B-cell lymphomas, particularly diffuse large B-cell lymphomas. POU2AF1 interacts with POU2F1 and SIAH1.
POU2AF1 is a transcriptional coactivator that specifically interacts with either POU2F1/OCT1 or POU2F2/OCT2. It enhances the promoter activity of POU2F1/OCT1 and to a lesser degree, that of POU2F2/OCT2. It recognizes the POU domains of both POU2F1/OCT1 and POU2F2/OCT2. POU2AF1 is essential for B-cell responses to antigens and required for the formation of germinal centers. It regulates IL6 expression in B cells as a POU2F2/OCT2 coactivator.
POU2AF1 is also known as BOB1, OBF-1, OBF1, OCAB.
