POM121
Description
The POM121 (POM121 transmembrane nucleoporin) is a protein-coding gene located on chromosome 7.
The nuclear envelope pore membrane protein POM 121 is a protein encoded by the POM121 gene in humans. Different protein isoforms are produced through alternative splicing, but the full-length structure of only one isoform has been determined. The nuclear envelope, which separates the nucleus from the cytoplasm in eukaryotic cells, is perforated by nuclear pores. These pores are large protein complexes that regulate the passage of macromolecules between the nucleus and cytoplasm. The nuclear pore complex (NPC) is composed of over 100 different protein subunits, many of which belong to the nucleoporin family. POM121 is a member of the FG-repeat-containing nucleoporins and is an integral membrane protein that localizes to the central spoke ring complex, where it plays a role in anchoring the NPC to the nuclear envelope. Antibodies against POM121 can be used to identify the nuclear envelope in immunofluorescence experiments.
POM121 is also known as P145, POM121A.
Associated Diseases
- COVID-19
- endometrial cancer
- thyroid gland adenocarcinoma
- esophageal cancer
- X-linked retinal dysplasia
- severe early-childhood-onset retinal dystrophy
- X-linked retinoschisis
- coloboma of optic nerve
