POLR2G
Description
The POLR2G (RNA polymerase II subunit G) is a protein-coding gene located on chromosome 11.
The POLR2G gene encodes the seventh largest subunit of RNA polymerase II, the enzyme responsible for synthesizing messenger RNA in eukaryotes. This subunit's association with the polymerase under suboptimal growth conditions in yeast suggests its role in regulating polymerase function.
POLR2G/RPB7 is a core component of RNA polymerase II (Pol II), the enzyme responsible for synthesizing mRNA precursors and various non-coding RNAs. It forms a subcomplex with POLR2D/RPB4, which binds to a pocket at the base of the clamp element, preventing double-stranded DNA from entering the active site and maintaining the clamp in a closed conformation. The POLR2D/RPB4-POLR2G/RPB7 subcomplex binds to single-stranded DNA and RNA.
POLR2G is also known as RPB19, RPB7, hRPB19, hsRPB7.
