POLR2F
Description
The POLR2F (RNA polymerase II, I and III subunit F) is a protein-coding gene located on chromosome 22.
DNA-directed RNA polymerases I, II, and III subunit RPABC2 is a protein that in humans is encoded by the POLR2F gene. This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes, that is also shared by the other two DNA-directed RNA polymerases. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template.
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This protein is a common component of RNA polymerases I, II, and III, which synthesize ribosomal RNA precursors, mRNA precursors, and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. RNA polymerase II (Pol II) is the central component of the basal RNA polymerase II transcription machinery. RNA polymerases are composed of mobile elements that move relative to each other. In Pol II, POLR2F/RPABC2 is part of the clamp element and, together with parts of POLR2A/RPB1 and POLR2B/RPB2, forms a pocket to which the POLR2D/RPB4-POLR2G/RPB7 subcomplex binds.
POLR2F is also known as HRBP14.4, POLRF, RPABC14.4, RPABC2, RPB14.4, RPB6, RPC15.
Associated Diseases
- PCWH syndrome
- Waardenburg syndrome
- Waardenburg-Shah syndrome
- Waardenburg syndrome type 1
- Hirschsprung disease
- acrocephalosyndactyly
- Kallmann syndrome
- endometrial cancer
- esophageal cancer
- Charcot-Marie-Tooth disease
- urinary bladder cancer
