PLIN5

• SHARE NOW |
• Tweet Opens in a new window.
• Pin it Opens in a new window.
• Share Opens in a new window.
• Share Opens in a new window.
• Email Opens in a new window.

---

Description

The PLIN5 (perilipin 5) is a protein-coding gene located on chromosome 19.

PLIN5, also known as Oxpatperilipin 5, is a protein belonging to the perilipin family, which is responsible for lipid droplet biogenesis, structure, and degradation. PLIN5 is specifically involved in maintaining the balance between lipolysis and lipogenesis, ensuring lipid droplet homeostasis. In oxidative tissues, such as muscle and cardiac tissue, PLIN5 promotes the association between lipid droplets and mitochondria. PLIN5 is found within various intracellular structures, including lipid droplets, the endoplasmic reticulum, mitochondria, and the cytosol. Abnormal expression of PLIN5 has been linked to diseases such as skeletal muscle diseases, liver diseases, and carcinogenesis. PLIN5 is one of five perilipins found in humans, all of which share similar functions related to lipid droplets. It exhibits high similarity to PLIN2 and PLIN3, with over 150 similar positions and an 18,644% similarity.

PLIN5 is a lipid droplet-associated protein that regulates the balance between lipogenesis and lipolysis, and plays a crucial role in fatty acid oxidation within oxidative tissues. It facilitates the recruitment of mitochondria to the surface of lipid droplets, contributing to lipid droplet homeostasis by controlling both the storage of fatty acids as triglycerides and the release of fatty acids for mitochondrial oxidation. In the process of lipid droplet triacylglycerol hydrolysis, PLIN5 acts as a scaffolding protein for key lipolytic players: ABHD5, PNPLA2, and LIPE. It reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering it to lipid droplets. Phosphorylation of PLIN5 by PKA activates lipolysis, likely through the release of ABHD5 from the perilipin scaffold and the promotion of its interaction with PNPLA2. Additionally, PLIN5 enhances lipolysis by interacting with LIPE and through PKA-mediated phosphorylation of LIPE.

PLIN5 is also known as LSDA5, LSDP5, MLDP, OXPAT.

Associated Diseases

• Wilson disease
• LIPE-related familial partial lipodystrophy
• type 2 diabetes mellitus
• coronary artery disease, autosomal dominant 2
• PLIN1-related familial partial lipodystrophy
• PPARG-related familial partial lipodystrophy
• familial partial lipodystrophy, Kobberling type
• AKT2-related familial partial lipodystrophy
• obesity due to melanocortin 4 receptor deficiency
• allergic disease