PLEKHG4

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Description

The PLEKHG4 (pleckstrin homology and RhoGEF domain containing G4) is a protein-coding gene located on chromosome 16.

Puratrophin-1 is a protein that in humans is encoded by the PLEKHG4 gene.

Plays a potential role in intracellular signaling pathways and the regulation of cytoskeletal dynamics, particularly at the Golgi apparatus.

PLEKHG4 is also known as ARHGEF44, PRTPHN1, SCA4.

Associated Diseases

• Spinocerebellar ataxia type 4