PLEKHF1
Description
The PLEKHF1 (pleckstrin homology and FYVE domain containing 1) is a protein-coding gene located on chromosome 19.
PLEKHF1 plays a role in apoptosis by triggering a cascade that ultimately leads to cell death. It translocates to the lysosome, causing the lysosomal membrane to become permeable. This release of lysosomal enzymes like CTSD and CTSL into the cytoplasm ultimately triggers caspase-independent apoptosis. It further influences mitochondrial membrane permeabilization, releasing PDCD8 and contributing to the apoptotic process.
PLEKHF1 is also known as APPD, LAPF, PHAFIN1, ZFYVE15.
