PLA2G4E
Description
The PLA2G4E (phospholipase A2 group IVE) is a protein-coding gene located on chromosome 15.
PLA2G4E, also known as cytosolic phospholipase A2 epsilon (cPLA2-epsilon), is a calcium-dependent N-acyltransferase involved in the biosynthesis of N-acyl ethanolamines (NAEs) in the brain. It catalyzes the transfer of the sn-1 fatty acyl chain from phosphatidylcholine (fatty acyl donor) to the amine group of phosphatidylethanolamine (fatty acyl acceptor) to produce N-acyl phosphatidylethanolamine (NAPE). PLA2G4E can also utilize plasmenylethanolamine as a fatty acyl acceptor to generate N-acyl plasmenylethanolamine (N-Acyl-PlsEt). Both NAPE and N-Acyl-PlsEt serve as precursors for bioactive NAEs such as N-arachidonoyl phosphatidylethanolamine, also known as anandamide. Additionally, PLA2G4E exhibits weak phospholipase A2 and lysophospholipase activities. It plays a role in regulating intracellular membrane trafficking by modulating membrane curvature through enrichment in lysophospholipids. PLA2G4E promotes tubule formation involved in clathrin-independent endocytotic trafficking and cargo recycling.
PLA2G4E is also known as -.
Associated Diseases
- acne inversa, familial, 3
- immunodeficiency 51
- familial reactive perforating collagenosis
- intellectual disability, FRA12A type
- erythrokeratodermia variabilis
- pityriasis rubra pilaris
- seborrhea-like dermatitis with psoriasiform elements
- peeling skin syndrome 6
