PLA2G2F
Description
The PLA2G2F (phospholipase A2 group IIF) is a protein-coding gene located on chromosome 1.
PLA2G2F, also known as Group IIF secretory phospholipase A2 (GIIF sPLA2, sPLA2-IIF) or Phosphatidylcholine 2-acylhydrolase 2F, is a secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. It hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids (phospholipase A2 activity), with a catalytic efficiency decreasing in the following order: phosphatidylglycerols > phosphatidylethanolamines > phosphatidylcholines > phosphatidylserines (PubMed:11112443). This enzyme may play a role in lipid mediator production in inflammatory conditions by providing arachidonic acid to downstream cyclooxygenases and lipoxygenases. This information is based on experimental evidence from UniProtKB:Q9QZT4 and PubMed:11112443.
PLA2G2F is also known as GIIFsPLA2, sPLA2-IIF.
