PKN3
Description
The PKN3 (protein kinase N3) is a protein-coding gene located on chromosome 9.
PKN3 is a protein kinase C-related molecule that is thought to mediate malignant cell growth downstream of activated phosphoinositide 3-kinase (PI3K). Chronic activation of the PI3K/PTEN signal transduction pathway is believed to contribute to metastatic cell growth, and PKN3 may play a role in this process. PKN3 has been shown to be required for invasive prostate cell growth in 3D cell culture assays and an orthotopic mouse tumor model through inducible expression of short hairpin RNA (shRNA). This suggests that PKN3 could be a target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of PI3K. PKN3 has been shown to interact with ARHGAP26.
PKN3 is also known as UTDP4-1.
