PIR-FIGF
Description
The PIR-FIGF (-) is a ncRNA gene located on chromosome X.
PIR-FIGF gene encodes Placental Growth Factor (PlGF), a protein essential for angiogenesis (blood vessel formation). It acts as a growth factor for endothelial cells, promoting their proliferation and migration, thereby facilitating the development of new blood vessels.
Placental Growth Factor (PlGF), also known as PIGF, is a protein that in humans is encoded by the PIR-FIGF gene. PlGF is a member of the vascular endothelial growth factor (VEGF) family and plays a crucial role in angiogenesis (the formation of new blood vessels). It acts as a potent mitogen and chemoattractant for endothelial cells, promoting their proliferation, migration, and tube formation. PlGF also contributes to vascular permeability and the regulation of blood vessel maturation. Its role in angiogenesis is particularly important during embryonic development, wound healing, and tumor growth. Moreover, PlGF levels are elevated during pregnancy and have been implicated in the pathophysiology of various diseases, including cardiovascular disease, cancer, and diabetic retinopathy.
PIR-FIGF is also known as -.
