PINX1
Description
The PINX1 (PIN2 (TERF1) interacting telomerase inhibitor 1) is a protein-coding gene located on chromosome 8.
PINX1, also known as PIN2/TERF1-interacting telomerase inhibitor 1 and PIN2 interacting protein 1, is a human gene. It serves as a telomerase inhibitor and may act as a tumor suppressor. PINX1 interacts with MCRS1, TERF1, and telomerase reverse transcriptase. There are two known variants of PINX1. The second variant has a frameshift compared to the first, resulting in a shorter protein with a distinct C-terminus. The longest PINX1 cDNA clone encodes a 328 amino acid protein with an N-terminal Gly-rich patch and a C-terminal TID domain (telomerase inhibitory domain). The TRF1 binding domain is located in the C-terminal 75 amino acids. Mouse PINX1 shares 74% identity with human PINX1.
PINX1 is a microtubule-binding protein crucial for accurate chromosome segregation. It facilitates the accumulation of TRF1 and TERT in the nucleolus, boosting TRF1's binding to telomeres. It also inhibits telomerase activity, potentially suppressing cell proliferation and acting as a tumor suppressor. These functions are supported by various studies (PubMed:15381700, PubMed:17198684, PubMed:19117989, PubMed:19265708, PubMed:19393617, PubMed:19553660).
PINX1 is also known as Gno1, LPTL, LPTS, Pxr1.
