PIN1
PIN1 Gene: A Key Regulator with Far-Reaching Implications
Description
The PIN1 gene encodes the peptidyl-prolyl isomerase NIMA-interacting 1 protein (PIN1), an enzyme that plays a pivotal role in cellular processes by regulating protein folding and protein-protein interactions. PIN1 binds to specific sites on target proteins, known as phosphorylated serine/threonine-proline motifs, and catalyzes the isomerization of proline residues, leading to conformational changes in the target protein.
Associated Diseases
Dysregulation of PIN1 has been implicated in a range of human diseases, including:
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Cancer: PIN1 overexpression has been observed in various cancers, including breast, prostate, and lung cancer. It promotes tumor growth, invasion, and metastasis by modulating cell cycle progression, apoptosis, and angiogenesis.
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Neurodegenerative disorders: PIN1 dysfunction has been linked to neurodegenerative diseases such as Alzheimer‘s and Parkinson‘s diseases. It affects protein homeostasis in the brain, leading to the accumulation of misfolded proteins and neuronal damage.
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Cardiovascular diseases: PIN1 has been implicated in the development of cardiovascular diseases like atherosclerosis and heart failure. It regulates vascular inflammation and smooth muscle cell migration, contributing to the progression of these conditions.
Did you Know ?
- PIN1 is the first peptidyl-prolyl isomerase found to be regulated by phosphorylation, a key mechanism that adds another layer of control to its diverse functions.
