PIM2
PIM2 Gene: A Detailed Guide to Function, Diseases, and Research
Description:
The PIM2 gene, also known as the PIM-2 proto-oncogene, is located on the long (q) arm of chromosome 6 at position 6q16. It encodes the PIM2 kinase, a member of the PIM family of serine/threonine kinases. PIM kinases play crucial roles in various cellular processes, including cell cycle regulation, proliferation, survival, and apoptosis.
Associated Diseases:
Mutations in the PIM2 gene have been implicated in several diseases, including:
- Cancer: PIM2 overexpression is commonly observed in various malignancies, including prostate, breast, lung, and colon cancers. It is associated with increased cell proliferation, resistance to apoptosis, and poor prognosis.
- Autoimmune diseases: Elevated PIM2 levels have been linked to the development of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus. PIM2 inhibition has shown promise in alleviating symptoms and reducing disease activity.
- Inflammatory diseases: PIM2 has been implicated in chronic inflammatory conditions, such as Crohn‘s disease and ulcerative colitis. PIM2 inhibitors have demonstrated therapeutic potential in reducing inflammation and improving disease outcomes.
Did you Know ?
Studies have shown that PIM2 overexpression is present in approximately 30-40% of all human cancers, underscoring its significant role in oncogenesis.
