PICK1
Description
The PICK1 (protein interacting with PRKCA 1) is a protein-coding gene located on chromosome 22.
Protein Interacting with C Kinase - 1 (PICK1) is a protein encoded by the PICK1 gene in humans. It contains a PDZ domain, which allows it to interact with protein kinase C, alpha (PRKCA). PICK1 functions as an adaptor protein, organizing the subcellular localization of various membrane proteins. It interacts with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, non-voltage gated sodium channels, and potentially targets PRKCA to these membrane proteins, regulating their distribution and function. PICK1 also acts as an anchoring protein, specifically targeting PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.
PICK1 is a protein that plays a crucial role in regulating the localization and function of various membrane proteins. It acts as an adapter protein, organizing the subcellular distribution of these proteins by binding to their PDZ recognition sequences. This function is involved in clustering receptors and potentially influencing their internalization. PICK1 is particularly important in synaptic plasticity, where it regulates the trafficking and internalization of AMPA receptors, contributing to the process of long-term depression. PICK1's activity can be influenced by the activation of protein kinase C alpha (PRKCA). It also regulates the activity of certain ion channels like ASIC1 and ASIC3. Notably, PICK1 interacts with the Arp2/3 complex, a key regulator of actin polymerization. PICK1 inhibits the actin-nucleating activity of this complex, contributing to neuronal morphology regulation and AMPA receptor endocytosis. This interaction is crucial for the regulation of synaptic plasticity and spine shrinkage during long-term depression. Furthermore, PICK1 influences astrocyte morphology by antagonizing the function of the Arp2/3 complex activator WASL/N-WASP.
PICK1 is also known as PICK, PRKCABP.
Associated Diseases
- male infertility due to globozoospermia
- Parkinson disease
- lysosomal storage disease
- Alzheimer disease
- multiple sclerosis
- male infertility with teratozoospermia due to single gene mutation
- partial chromosome Y deletion
- acute kidney failure
- spermatogenic failure 65
- spermatogenic failure 39
- spermatogenic failure, X-linked, 3
- spermatogenic failure 63
- spermatogenic failure 72
- spermatogenic failure 51
