PI4KB
Description
The PI4KB (phosphatidylinositol 4-kinase beta) is a protein-coding gene located on chromosome 1.
PI4KB is a human gene that encodes a phosphatidylinositol 4-kinase (PI4K) enzyme. This enzyme adds a phosphate group to phosphatidylinositol, generating phosphatidylinositol 4-phosphate (PI4P). PI4P is an essential molecule involved in cellular signaling and trafficking, particularly within the Golgi apparatus and the trans Golgi network. PI4KB itself is a soluble protein that moves between the cytoplasm and the nucleus, and can be recruited to the Golgi membranes through interactions with proteins like Arf1, Rab11, and ACBD3. PI4KB can be activated by phosphorylation by protein kinase D, which enhances its interaction with 14-3-3 proteins and stabilizes it in its active form. In the cytoplasm, PI4KB regulates transport from the Golgi to the cell membrane. However, its function within the nucleus remains unknown. Some viruses, including picornaviruses, exploit PI4KB to create specialized membrane compartments called membranous webs, which they use as platforms for replication within the host cell.
PI4KB phosphorylates phosphatidylinositol (PI), initiating the production of the signaling molecule inositol-1,4,5,-trisphosphate (PIP). It may regulate Golgi apparatus breakdown and reorganization during cell division, potentially through its own phosphorylation. PI4KB is involved in the transport of molecules from the Golgi apparatus to the cell membrane. It might play a role in the development of the inner ear.
PI4KB is also known as DFNA87, NPIK, PI4K-BETA, PI4K92, PI4KBETA, PI4KIII, PI4KIIIBETA, PIK4CB.
