PGBD5
Description
The PGBD5 (piggyBac transposable element derived 5) is a protein-coding gene located on chromosome 1.
PGBD5 is an enzyme encoded by the PGBD5 gene in humans. It is a DNA transposase related to the ancient PiggyBac transposase found in the cabbage looper moth. PGBD5 is believed to have been domesticated over 500 million years ago in the common ancestor of cephalochordates and vertebrates. It has a conserved catalytic triad, distinct from other PiggyBac-like genes, and can transpose DNA in a sequence-specific, cut-and-paste fashion. PGBD5 has been suggested to mediate site-specific DNA rearrangements in human tumors. Human PGBD5 can mobilize insect PiggyBac transposons in human cell culture.
In mature mice brains, PGBD5 is primarily found in the olfactory bulb, hippocampus, and cerebellum. In embryonic mice brains, PGBD5 is found in areas that develop into the hippocampus, cerebellum, hypothalamus, and medulla.
PGBD5 is expressed in the majority of human pediatric solid tumors.
PGBD5 is a transposase that mediates sequence-specific genomic rearrangements (PMID:26406119, PMID:28504702). It can induce genomic rearrangements that inactivate the HPRT1 gene (PMID:27491780).
PGBD5 is also known as -.
