PFKP
Description
The PFKP (phosphofructokinase, platelet) is a protein-coding gene located on chromosome 10.
PFKP (Phosphofructokinase, platelet) is an enzyme encoded by the PFKP gene. It catalyzes the irreversible conversion of fructose 6-phosphate to fructose 1,6-bisphosphate, a key regulatory step in glycolysis. PFKP is expressed in platelets, fibroblasts, and other tissues. It forms a tetrameric enzyme with different isoforms, including PFKM (muscle) and PFKL (liver). The specific subunit composition of the tetrameric PFK enzyme influences its kinetic and regulatory properties.
PFKP catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate using ATP. This is the first irreversible step in glycolysis, committing the cell to glucose breakdown.
PFKP is also known as ATP-PFK, PFK-C, PFK-P, PFKF.
Associated Diseases
- Parkinson disease
- multiple sclerosis
- Alzheimer disease
- lysosomal storage disease
- endometrial cancer
- cancer
