PERM1
Description
The PERM1 (PPARGC1 and ESRR induced regulator, muscle 1) is a protein-coding gene located on chromosome 1.
PERM1 (PGC-1 and ERR-induced regulator in muscle protein 1) plays a crucial role in regulating the expression of specific genes that are activated by PPARGC1A/B and ESRRA/B/G. These genes are involved in various metabolic processes, including glucose and lipid metabolism, energy transfer, muscle contraction, mitochondrial formation in muscle cells, and the ability of cells to utilize oxygen. PERM1 is essential for the proper activation of genes like MT-CO2, MT-CO3, COX4I1, TFB1M, TFB2M, POLRMT, and SIRT3, which are all triggered by PPARGC1A. Additionally, PERM1 enhances the expression of CKMT2, TNNI3, and SLC2A4 genes, while it suppresses the expression of PDK4, all in response to the combined action of PPARGC1A and ESRRG.
PERM1 is also known as C1orf170.
