PELI3
Description
The PELI3 (pellino E3 ubiquitin protein ligase family member 3) is a protein-coding gene located on chromosome 11.
PELI3 is an E3 ubiquitin ligase that catalyzes the covalent attachment of ubiquitin moieties onto substrate proteins. It is involved in the TLR and IL-1 signaling pathways by interacting with the complex containing IRAK kinases and TRAF6. PELI3 mediates 'Lys-63'-linked polyubiquitination of IRAK1 and can activate AP1/JUN and ELK1. PELI3 also acts as a regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of RIPK2 downstream of NOD1 and NOD2, thereby transforming RIPK2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF-kappa-B and MAP kinases signaling. PELI3 catalyzes 'Lys-63'-linked polyubiquitination of RIPK2 in parallel of XIAP. PELI3 interacts with TRAF6, MAP3K14 and MAP3K7.
PELI3 is also known as -.
