PDLIM4
Description
The PDLIM4 (PDZ and LIM domain 4) is a protein-coding gene located on chromosome 5.
PDZ and LIM domain protein 4 is a protein that in humans is encoded by the PDLIM4 gene.
Isoform 1 of PDLIM4 suppresses SRC activation by binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC'Tyr-419', leading to SRC inactivation. This process involves PTPN13, a protein tyrosine phosphatase. Inactivated SRC then dissociates from PDLIM4, allowing a new SRC inactivation cycle to begin. PDLIM4 plays a role in the reorganization of the actin cytoskeleton. In nonmuscle cells, it binds to ACTN1 (alpha-actinin-1), increasing ACTN1's affinity to F-actin (filamentous actin) and promoting the formation of actin stress fibers. It also regulates synaptic AMPA receptor transport in the dendritic spines of hippocampal pyramidal neurons, directing the receptors toward insertion at the postsynaptic membrane. PDLIM4 links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton, which ultimately increases AMPA receptor-mediated excitatory postsynaptic currents in neurons.
PDLIM4 is also known as RIL.
