PCGF5
Description
The PCGF5 (polycomb group ring finger 5) is a protein-coding gene located on chromosome 10.
Polycomb group RING finger protein 5 is a protein that in humans is encoded by the PCGF5 gene.
PCGF5 is a component of a Polycomb group (PcG) multiprotein PRC1-like complex. This complex class is essential for maintaining the transcriptionally repressive state of numerous genes, including Hox genes, throughout development. The PcG PRC1 complex functions through chromatin remodeling and histone modification, specifically by mediating monoubiquitination of histone H2A 'Lys-119'. This modification results in heritable changes in chromatin expressibility. Within the PRC1-like complex, PCGF5 regulates RNF2 ubiquitin ligase activity. Additionally, PCGF5 plays a redundant role with PCGF3 in a PRC1-like complex that monoubiquitinates histone H2A 'Lys-119' on the X chromosome, which is crucial for the normal silencing of one X chromosome copy in XX females.
PCGF5 is also known as RNF159.
