PARD6G
Description
The PARD6G (par-6 family cell polarity regulator gamma) is a protein-coding gene located on chromosome 18.
PAR6G, also known as PAR6D, acts as an adapter protein in crucial cellular processes, including asymmetrical cell division and the establishment of cell polarity. It is believed to contribute to the formation of epithelial tight junctions, which are vital for maintaining tissue integrity. This protein collaborates with PARD3 to form a complex that bridges GTP-bound Rho small GTPases, key regulators of cellular processes, with atypical protein kinase C proteins. This connection plays a critical role in coordinating signaling pathways essential for cell behavior.
PARD6G is also known as PAR-6G, PAR6gamma.
Associated Diseases
- osteoarthritis
- cancer
- Adams-Oliver syndrome
- tuberculosis
- cystic fibrosis
- Prader-Willi syndrome
- Beckwith-Wiedemann syndrome
- pseudohypoparathyroidism
