PARD6A

Description

The PARD6A (par-6 family cell polarity regulator alpha) is a protein-coding gene located on chromosome 16.

PARD6A is a protein encoded by the PARD6A gene in humans. It is a member of the PAR6 family and contains a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. As a cell membrane protein, it participates in asymmetric cell division and cell polarization as part of a multi-protein complex. PARD6A is also involved in the epithelial-to-mesenchymal transition (EMT), which characterizes the invasive phenotype of metastatic carcinomas. Different isoforms of the protein are encoded by alternative splicing. Recent studies have shown that Par6 associates with PKC-ι in melanoma, promoting melanoma cell invasion by upregulating the PKC-ι/Par6 pathway during EMT. Inhibition or knockdown of PKC-ι increases E-cadherin and RhoA levels while decreasing total Vimentin, phosphorylated Vimentin (S39) and Par6 in metastatic melanoma cells, suggesting a role for PKC-ι in EMT signaling pathways. PARD6A has been shown to interact with CDC42, ECT2, Protein kinase Mζ, RAC1, and Protein kinase C-ι.

PARD6A, also known as PAR-6, PAR-6 alpha, PAR-6A, PAR6C, or Tax interaction protein 40, is an adapter protein involved in asymmetric cell division and cell polarization processes. It is believed to play a role in the formation of epithelial tight junctions. Its association with PARD3 may prevent PARD3 from interacting with F11R/JAM1, thus preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. PARD6A also regulates centrosome organization and function, being essential for the centrosomal recruitment of proteins that control centrosomal microtubule organization.

PARD6A is also known as PAR-6A, PAR6, PAR6C, PAR6alpha, TAX40, TIP-40.

Associated Diseases

WES Whole Exome Sequencing

Clinical Exome Sequencing