P4HA1
Description
The P4HA1 (prolyl 4-hydroxylase subunit alpha 1) is a protein-coding gene located on chromosome 10.
The P4HA1 gene in humans encodes a component of prolyl 4-hydroxylase, an enzyme crucial for collagen synthesis. This enzyme is composed of two identical alpha subunits (encoded by P4HA1) and two beta subunits. The protein encoded by P4HA1 is one of several alpha subunit types and forms the major part of the active enzyme's catalytic site. Prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline in newly synthesized procollagen chains, essential for their proper three-dimensional folding. Variations in the gene due to alternative splicing lead to different isoforms of the protein.
This enzyme catalyzes the formation of 4-hydroxyproline in specific sequences (-Xaa-Pro-Gly-) within collagen and other proteins.
P4HA1 is also known as P4HA.
