P2RX2
Description
The P2RX2 (purinergic receptor P2X 2) is a protein-coding gene located on chromosome 12.
P2RX2 is a protein encoded by the P2RX2 gene in humans. It belongs to the purinoceptor family, which are receptors for ATP. This receptor acts as a cation-conducting ligand-gated ion channel. Binding of ATP to this receptor mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants have been identified for this gene, each encoding a distinct isoform.
P2RX2 is an ion channel activated by extracellular ATP, playing a role in various cellular processes. It contributes to excitatory postsynaptic responses in sensory neurons, neuromuscular junction formation, hearing, taste perception, and peristalsis. In the inner ear, it regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and potassium recycling. Additionally, it mediates synaptic transmission between neurons and from neurons to smooth muscle.
P2RX2 is also known as DFNA41, P2X2.
